Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
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چکیده
منابع مشابه
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
Autophagy is a homeostatic process that is important for degrading protein aggregates, nutrient deposits, dysfunctional organelles and several signaling molecules. p62/sequestosome-1 is a protein that binds to several autophagy substrates, such as ubiquitinated proteins, damaged mitochondria and signaling molecules such as an Nrf2 inhibitor Keap1, promoting their autophagic degradation. Sestrin...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2014
ISSN: 1742-464X
DOI: 10.1111/febs.12905